The Hippo pathway serves as a key barrier for oncogenic transformation. It acts by limiting\nthe activity of the proto-oncogenes YAP and TAZ. Reduced Hippo signaling and elevated YAP/TAZ\nactivities are frequently observed in various types of tumors. Emerging evidence suggests that\nthe ubiquitin system plays an important role in regulating Hippo pathway activity. Deregulation\nof ubiquitin ligases and of deubiquitinating enzymes has been implicated in increased YAP/TAZ\nactivity in cancer. In this article, we review recent insights into the ubiquitin-mediated regulation of\nthe mammalian Hippo pathway, its deregulation in cancer, and possibilities for targeting the Hippo\npathway through the ubiquitin system.
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